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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Mini Review on Helical Polymers for Disease Treatment and Tissue Repair.

Qian Wang1, Xiang-Huan Shan1, Xin Shen1

  • 1College of Materials and Chemical Engineering, West Anhui University, Lu'an, China.

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Helical polymers, including DNA and proteins, are vital in organisms and offer potential for new biomedical materials. This review explores their applications in disease treatment and tissue repair.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Molecular Biology

Background:

  • Helical structures like DNA and proteins are fundamental to life.
  • Their unique configuration offers broad application potential.
  • Understanding helical macromolecules aids in comprehending life and developing novel materials.

Purpose of the Study:

  • To review natural and synthesized helical polymers.
  • To summarize their applications in biomedical fields.
  • To discuss formation, challenges, and future perspectives.

Main Methods:

  • Review of natural helical polymers (polysaccharides, DNA derivatives, peptide derivatives).
  • Review of synthesized helical polymers (polyisocyanides).
  • Summary of applications in disease treatment, drug delivery, and tissue repair.

Main Results:

  • Helical polymers demonstrate significant potential in antibacterial therapy.
  • They serve as effective delivery systems for therapeutic agents.
  • Applications in tissue repair highlight their regenerative capabilities.

Conclusions:

  • Helical polymers are versatile biomaterials with diverse therapeutic applications.
  • Further research into their formation and properties can overcome current challenges.
  • Future perspectives indicate expanded use in advanced biomedical materials.