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Consensus recommendations on tear fluid terminology: A Delphi study by the tear research network
Jente Schmeetz1, Rupesh Agrawal2, Carlos Cifuentes-González3
1University Eye Clinic, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands.
Summary
Standardized definitions for tear fluid and tear film were established by international experts. This consensus improves consistency in ocular disease and biomarker research, enhancing data comparability and clinical translation.
Area of Science:
- Ophthalmology
- Biomarker Research
- Proteomics
Background:
- Tear fluid is crucial for ocular disease and biomarker research.
- Inconsistent terminology hinders data comparability and clinical translation.
- Standardized definitions are needed for tear-related research.
Purpose of the Study:
- Establish standardized definitions for tear fluid synonyms.
- Improve terminology consistency in ocular research.
- Facilitate data comparability and clinical translation.
Main Methods:
- International Delphi consensus study.
- Two rounds of online surveys.
- 103 international researchers participated.
Main Results:
- Consensus reached on definitions for localization, source, function, use, and collection.
- Standardized glossary developed.
- Strongest agreement (>90%) for 'tear fluid' and 'tear film'.
- Tear fluid: body fluid and sample. Tear film: ocular surface structure.
Conclusions:
- Recommendations support research comparability.
- Promote consistent reporting and interdisciplinary communication.
- Enhance future tear-related studies.
