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Bidirectional association between irritable bowel syndrome and depression among probands and unaffected siblings: A
Hsin-Ya Kuo1, Tien-Wei Hsu2, Che-Sheng Chu3
1Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Objective:
This study investigated whether irritable bowel syndrome (IBS) and depression coaggregate within families and whether their association is bidirectional, by comparing probands with IBS or depression and their unaffected siblings.
Methods:
We used the Taiwan National Health Insurance Research Database (NHIRD) to construct an IBS cohort consisting of 2534 affected probands, 2683 unaffected siblings, and 10,732 matched controls, and then evaluated subsequent depression risk. We also constructed a depression cohort including 30,961 affected probands, 34,326 unaffected siblings, and 137,304 matched controls to investigate the later risk of IBS.
Results:
Patients with IBS [odds ratio (OR) = 1.27, 95% confidence interval (CI): 1.16-1.38] and unaffected siblings (OR = 1.20, 95% CI: 1.10-1.31) were associated with an increased risk of depression later in life compared with the non-IBS reference group. Moreover, relative to the non-depression reference group, both patients with depression (OR = 2.22, 95% CI = 1.80-2.74) and their unaffected siblings (OR = 1.30, 95% CI = 1.02-1.66) had an increased risk of developing IBS over the follow-up period.
Conclusions:
The observed bidirectional association between IBS and depression in probands and their unaffected siblings supports the presence of familial coaggregation between these two conditions. Further work is needed to clarify the respective contributions of genetic and environmental factors to this association.
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