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PARP Gene Variants and Male Infertility: A Genetic Prescriptive From a North-Indian Cohort
Bhawani Sharma1, Ruchi Shah1, Raju Shankarayan1
1School of Biotechnology, Shri Mata Vaishno Devi University, Katra, India.
Urology
|March 22, 2026
Summary
Genetic variants in PARP14 and PARP15 genes are linked to male infertility risk in North India. Specific PARP14 variants increase risk, while PARP15 variants show a protective effect, highlighting DNA repair
Area of Science:
- Genetics and Reproductive Biology
- Molecular Mechanisms of Infertility
- Population Genetics in South Asia
Background:
- Male infertility affects a significant portion of the reproductive-aged population globally.
- Poly (ADP-ribose) polymerase (PARP) family genes are crucial for DNA repair, a process vital for spermatogenesis.
- Limited research exists on the genetic underpinnings of male infertility in South Asian populations.
Purpose of the Study:
- To investigate the association between specific gene variants in PARP14 (rs11719086) and PARP15 (rs12489170) and the risk of male infertility.
- To explore the role of DNA repair gene polymorphisms in spermatogenesis.
- To provide insights into region-specific genetic factors influencing male fertility in North India.
Main Methods:
- A case-control study involving 222 infertile men and 360 fertile controls from Jammu and Kashmir, North India.
- Genotyping of single nucleotide polymorphisms (SNPs) PARP14 rs11719086 and PARP15 rs12489170 using TaqMan allelic discrimination assay.
- Statistical analysis employing multivariable logistic regression, adjusting for age, BMI, smoking, and alcohol use.
Main Results:
- The PARP14 rs11719086 variant showed a strong association with increased male infertility risk (OR = 4.41, p = 3.76×10-13) under the dominant model.
- The PARP15 rs12489170 variant demonstrated a moderate protective effect against male infertility (OR = 0.579, p = 0.006) under the dominant model.
- These findings suggest distinct roles for PARP14 and PARP15 in male reproductive health.
Conclusions:
- This study is the first to link PARP14 and PARP15 gene variants to male infertility in North India.
- The results underscore the importance of DNA repair pathways in successful spermatogenesis.
- Further validation in larger cohorts is recommended to confirm these findings and explore their clinical utility for predictive diagnostics and tailored treatments in South Asian populations.
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