Plasma concentrations following oral administration of two different forms of resveratrol in horses

Resveratrol is a compound found in multiple plants and there is evidence for its use as a supplement in horses, particularly through protection of chondrocytes. Previous studies on the clinical efficacy of resveratrol supplementation in horses have reported limited benefits. To date, there is no pharmacokinetic data of resveratrol in horses but the bioavailability of resveratrol in other species is poor. In this crossover study, the plasma concentrations of two forms of resveratrol were examined. Each horse received via nasogastric tube, either a single dose of resveratrol phospholipid or a standardized resveratrol extract (NMXRS37™) separated by a 6-week washout period. Plasma samples for resveratrol concentrations were taken at 1 hour prior to administration and at 0.5, 1-, 2-, 4-, 8-, 12-, and 24-hours post administration. Results indicated resveratrol is bioavailable in horses. There were no significant differences in C_max, T_max, or AUC between the compounds. No adverse effects related to resveratrol administration were observed.