Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

403
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
403
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

520
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
520
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

927
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
927
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

1.0K
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
1.0K
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

745
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
745
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

426
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
426

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative midterm results of surgical mitral valve replacement and transcatheter mitral valve replacement with the Tendyne System.

JTCVS structural and endovascular·2026
Same author

Hybrid aortic arch replacement with a modified stent bridging for the left subclavian artery.

JTCVS techniques·2026
Same author

Transapical Bioprosthetic Leaflets Removal to Prevent Left Ventricular Outflow Tract Obstruction During Mitral Valve-in-Valve.

JACC. Cardiovascular interventions·2026
Same author

The Austrian Adult Cardiac Surgery Registry: Structure and Governance of a National Quality Assurance System.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same author

Early outcomes of redo-TAVI with the SAPIEN 3 platform: the prospective, multicentre ReTAVI registry.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2026
Same author

A.Kocher Technique: A Simplified Universally Applicable Approach for Aortic Root Enlargement.

Innovations (Philadelphia, Pa.)·2026

Related Experiment Video

Updated: Mar 24, 2026

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
09:57

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

3.3K

CT-Based Annular Dimensions in Transcatheter Mitral Valve Replacement: A Multicenter Registry Study.

Liliane Zillner1, Mirjam G Wild2, Michaela M Hell3

  • 1Department of Cardiac and Thoracic Aortic Surgery, Medical University of Vienna, Austria.

The Annals of Thoracic Surgery
|March 22, 2026
PubMed
Summary

Larger mitral annulus dimensions and increased Annular Area Loss predict one-year cardiac death in transcatheter mitral valve replacement (TMVR) patients. Comprehensive annular assessment aids patient selection for TMVR.

More Related Videos

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.6K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.7K

Related Experiment Videos

Last Updated: Mar 24, 2026

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
09:57

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

3.3K
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.6K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.7K

Area of Science:

  • Cardiovascular Interventions
  • Cardiac Imaging
  • Structural Heart Disease

Background:

  • Transcatheter mitral valve replacement (TMVR) is a key intervention for severe mitral regurgitation in high-risk patients.
  • The prognostic role of mitral annular dimensions in TMVR, particularly with native leaflets, remains underexplored.

Purpose of the Study:

  • To investigate the association between preprocedural 4D-CT-derived mitral annular dimensions and mortality outcomes in TMVR patients.
  • To evaluate the predictive value of Annular Area Loss for cardiac mortality post-TMVR.

Main Methods:

  • Subanalysis of the multicenter TENDER registry including 145 TMVR patients.
  • Preprocedural 4D-CT was used to assess annular dimensions.
  • Association between annular parameters and cardiac/all-cause mortality at one year was analyzed.

Main Results:

  • One-year all-cause mortality was 24.8% and cardiac mortality was 5.5%.
  • Larger annular dimensions (anteroposterior diameter, perimeter, area) were significantly associated with cardiac deaths.
  • Greater Annular Area Loss was significantly associated with cardiac mortality (OR=1.005, p=0.030).

Conclusions:

  • Increased mitral annular dimensions and Annular Area Loss are potential predictors of one-year cardiac death after TMVR.
  • Mechanisms may involve impaired left ventricular filling and outflow tract obstruction.
  • Detailed annular assessment can improve patient selection for TMVR, especially for transseptal delivery systems.