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Identification of novel blood-borne soluble binding partners of factor H-related proteins

Jiaqi Tang1, Franziska Woerz1, Tina Beyer1

  • 1Department of Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University of Tübingen, Tübingen, Germany.

Scientific Reports
|March 23, 2026
PubMed
Abstract

No abstract available in PubMed .

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When drugs enter systemic circulation, they interact with various components of the blood, including proteins such as human serum albumin (HSA), α1-acid glycoprotein (AAG), lipoproteins, globulins, and red blood cells (RBCs).
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are...
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