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Updated: Mar 24, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Recent structural modification in halogenated flavonoids: a review
Yunjie He1, Zhao Zhao1, Xianheng Wang2
1Pharmacy School, Zunyi Medical University, Zunyi, China.
Halogenation enhances the biological activity of natural flavonoids, showing promise for developing new drugs. This review covers recent advances in modifying flavonoids with halogens for medicinal applications.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Pharmacology
Background:
- Flavonoids are plant-derived compounds with significant anti-inflammatory, anti-tumor, and anti-oxidation properties.
- These natural products are utilized across food, medicine, and various industries.
- Modification of natural compounds is a key strategy in drug discovery.
Purpose of the Study:
- To review recent advancements in the halogenation modification of natural flavonoids.
- To summarize the enhanced biological activities of halogenated flavonoids.
- To provide a reference for developing novel halogenated flavonoid-based drugs.
Main Methods:
- Literature review of scientific publications on flavonoid halogenation.
- Analysis of studies reporting biological activities of modified flavonoids.
- Synthesis and characterization of halogenated flavonoid derivatives (as reported in literature).
Main Results:
- Halogenation significantly boosts the anti-inflammatory, anti-tumor, and anti-oxidation effects of flavonoids.
- Specific halogenation patterns correlate with increased potency and altered activity profiles.
- Emerging evidence supports the therapeutic potential of these modified compounds.
Conclusions:
- Halogenated flavonoids represent a promising class of compounds for pharmaceutical development.
- Further research into structure-activity relationships can optimize drug design.
- This review highlights the potential of halogenation as a strategy to enhance flavonoid efficacy.
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