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Updated: Mar 24, 2026

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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Suicidality and Drug Use Behavior Among Perinatal Individuals in Recovery
Medrxiv : the Preprint Server for Health Sciences
|March 23, 2026
Summary
Maternal mental health conditions like suicidal thoughts and behaviors (SITB) are linked to perinatal drug use. SITB is associated with opioid cravings, anxiety, depression, bipolar disorder, and increased cannabis and nicotine use.
Area of Science:
- Perinatal mental health
- Obstetrics and Gynecology
- Addiction Medicine
Background:
- Maternal mental health conditions are the leading cause of maternal mortality in the U.S.
- The relationship between perinatal suicidality and drug use is not well understood.
- Racial disparities exist in U.S. suicide and drug use rates.
Purpose of the Study:
- To examine the association between suicidality and drug use behavior in perinatal individuals.
- To investigate racial differences in suicidality and drug use among perinatal individuals.
Main Methods:
- Participants were recruited from a High-Risk Obstetric & Gynecological Clinic.
- A sub-sample (N=66) of individuals in an mHealth intervention for opioid and stimulant use disorders were analyzed (n=43).
- Chi-square and t-tests were used to assess associations between lifetime suicidality and perinatal drug use.
Main Results:
- Nearly 40% of the sample reported a history of suicidal thoughts and behaviors (SITB), with 87% having a previous suicide attempt.
- SITB was significantly associated with opioid cravings, perinatal anxiety, depression, bipolar disorder, recent cannabis use, and nicotine use.
- White mothers reported more overdoses, while Black mothers reported higher opioid cravings during pregnancy.
Conclusions:
- A history of SITB is a distinct risk factor for perinatal drug use.
- SITB frequently co-occurs with other perinatal mental health conditions.
- Further research is needed to understand the complex interplay between drug use and suicidality.
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