Related Experiment Video
Updated: Mar 24, 2026
11:17
A Microscopic 2,3,5-Triphenyltetrazolium Chloride Assay for Accurate and Reliable Analysis of Myocardial Injury
Published on: November 28, 2025
443
Free Triiodothyronine as a Biomarker for Ventricular Arrhythmia Following Myocardial Infarction: A Multicenter
Li Deng1,2, Yunlai Gao1, Lu Pan1
1Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital, Wuxi, Jiangsu, 214001, People's Republic of China.
Clinical Interventions in Aging
|March 23, 2026
Summary
Low plasma free triiodothyronine (FT3) levels are linked to a higher risk of ventricular arrhythmias (VA) in acute myocardial infarction (AMI) patients. This finding highlights FT3 as a potential predictor for VA in this population.
Area of Science:
- Cardiology
- Endocrinology
- Clinical Research
Background:
- The association between plasma free triiodothyronine (FT3) and ventricular arrhythmias (VA) in acute myocardial infarction (AMI) patients is not well-established.
- Understanding this relationship is crucial for risk stratification and management of AMI.
Purpose of the Study:
- To investigate the influence of plasma FT3 levels on the occurrence of VA in patients hospitalized with AMI.
- To determine if FT3 serves as an independent predictor of VA risk in AMI.
Main Methods:
- A prospective, multicenter study included 3277 patients diagnosed with AMI between January 2018 and December 2021.
- Patients were divided into Ventricular Arrhythmia (VA) and Non-VA groups for FT3 level comparison.
- Multivariate logistic regression analyses were employed to assess the association between FT3 levels and VA risk.
Main Results:
- Patients who developed VA had significantly lower FT3 levels compared to those without VA ([3.74 ± 0.77 pmol/L] vs [4.13 ± 0.81 pmol/L], P < 0.001).
- Lower FT3 levels were identified as an independent predictor of VA risk (adjusted OR: 0.761; 95% CI: 0.591-0.980; P = 0.035).
- A dose-dependent relationship was observed, with decreasing VA risk associated with increasing FT3 quartiles (P_trend = 0.007).
Conclusions:
- This study confirms a significant association between lower plasma FT3 levels and an increased risk of ventricular arrhythmias in patients with acute myocardial infarction.
- Plasma FT3 levels may serve as a valuable biomarker for predicting VA risk in hospitalized AMI patients.
Keywords:
acute myocardial infarctionbiomarkerdiagnosis and predictionfree triiodothyronineprospective cohort studyventricular arrhythmiaMore Related Videos
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
1.1K
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.1K
01:30Acute Coronary Syndrome III: Diagnostic Studies
411
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
411
01:30Dysrhythmias V: Evaluating Dysrhythmias
471
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
471
01:12Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
2.9K
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
2.9K
01:25ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
887
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
887
01:27Myocarditis II: Clinical Features and Diagnostic Tests
438
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
438