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Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
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Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
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Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
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Reticular fiber distribution in sclera: Key to understanding pathologic myopia and posterior staphylomas.

Hirohiko Kakizaki1,2, Heebae Ahn2, Muhammad Abumanhal3

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Summary

Reticular fiber density in the human sclera varies significantly between individuals and regions. This variability may contribute to pathologic myopia and posterior staphyloma development, suggesting broader areas of scleral vulnerability.

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Area of Science:

  • Ophthalmology
  • Histology
  • Biomedical Engineering

Background:

  • The sclera provides structural integrity to the eye.
  • Understanding scleral composition is crucial for eye disease research.
  • Reticular fibers are key components of connective tissue.

Purpose of the Study:

  • To map reticular fiber distribution in the human sclera.
  • To investigate the role of these fibers in myopia and posterior staphyloma.

Main Methods:

  • Human scleral sections from 13 cadaver eyes were analyzed.
  • Specimens were stained for reticular fibers and imaged.
  • ImageJ software quantified fiber density in three scleral regions.

Main Results:

  • Significant inter- and intraindividual variability in reticular fiber density was observed.
  • The pars plana consistently showed higher reticular fiber density compared to other regions.
  • Density varied considerably across different clock-hour positions.

Conclusions:

  • Scleral reticular fiber distribution is highly variable.
  • Structural vulnerabilities may exist beyond the posterior pole.
  • Reduced reticular fiber density could be linked to myopia progression and posterior staphyloma.