Related Experiment Video

Updated: Mar 24, 2026

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
05:49

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Published on: May 5, 2021

5.6K

Poor glycemic control impairs recovery from central retinal vein occlusion

Konstantin Y Gushansky1, Petteri Karesvuo2,3, Raimo Tuuminen2,4,5

  • 1Department of Ophthalmology, Assuta Samson Medical Center, Ashdod, Israel.

Molecular Vision
|March 23, 2026
PubMed

Insights

Poor glycemic control in patients with central retinal vein occlusion (CRVO) is linked to increased central macular thickness. Maintaining optimal blood sugar levels is crucial for better retinal outcomes in CRVO patients.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Retinal Diseases

Background:

  • Central retinal vein occlusion (CRVO) is a significant cause of vision loss.
  • Glycemic control is a critical factor in managing diabetes and its complications.
  • Suboptimal glycemic control may impact retinal health in CRVO patients.

Purpose of the Study:

  • To investigate the association between poor glycemic control and central macular thickness (CMT) in patients with CRVO.
  • To evaluate the longitudinal changes in CMT over a 1-year period in relation to glycemic status.

Main Methods:

  • Retrospective cohort study of adult CRVO patients with HbA1c measurements.
  • Patients categorized into good (≤42 mmol/mol) and poor (>42 mmol/mol) glycemic control groups.
  • Central macular thickness and visual acuity assessed at baseline, 3 months, and 1 year.

Main Results:

  • Patients with poor glycemic control exhibited significantly higher CMT at 3 months and 1 year compared to those with good control.
  • HbA1c levels showed a correlation with CMT at 3 months (R² = 0.514, p = 0.045).
  • The correlation between HbA1c and CMT did not reach statistical significance at the 1-year follow-up (R² = 0.246, p = 0.071).

Conclusions:

  • Suboptimal glycemic control is associated with increased central macular thickness in CRVO patients.
  • These findings highlight the importance of achieving and maintaining optimal glycemic control to mitigate retinal complications in CRVO.
  • Effective diabetes management may improve long-term visual outcomes for individuals with CRVO.
Abstract

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

7.1K
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

3.3K

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.4K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.4K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.3K
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K