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Updated: Mar 24, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Cyclometalated Platinum Compounds from Competing C-H/C-X Bond Activation Pathways
Craig M Anderson1, Matthew W Greenberg1, Christopher N LaFratta1
1Department of Chemistry & Biochemistry, Bard College, 30 Campus Road, Annandale-on-Hudson, New York 12504, United States.
Abstract:
X-C^N^N (X = Br, Cl) ligands were reacted with [Pt2Me4(μ-SMe2)2], 1, resulting in a six-coordinate cyclometalated platinum-(IV) compound containing an anionic C^N^N ligand when X = Br and both a platinum-(IV) and a platinum-(II) product when X = Cl. The platinum-(II) species was formed by C-H activation, followed by reductive elimination of methane. The platinum compounds were characterized by multinuclear NMR spectroscopy and single-crystal X-ray diffraction (SCXRD). Photophysical properties were explored by using UV/vis, emission, and transient absorption (TA) spectroscopies. DFT and TDDFT calculations were performed to examine the competition between C-H activation and C-X oxidative addition and compared to experimental results.
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