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Updated: Mar 24, 2026

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Peri-implantitis: a systemic burden for our patients.

Emilio A Cafferata1,2, Frank Schwarz2

  • 1Oral Peri-Implant Research Group, Department of Oral Implantology, Postgraduate School of Dentistry, Universidad Científica del Sur, Lima, Perú.

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|March 23, 2026
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Summary

Peri-implantitis, an oral inflammatory disease, can cause systemic inflammation, potentially impacting organs like the heart and brain. Treating this condition may improve overall health and reduce inflammatory markers.

Keywords:
chronic inflammationinflammationinflammatory mediatorsperi-implant diseasesystemic diseasesystemic inflammation

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Area of Science:

  • Oral Health
  • Systemic Inflammation
  • Medical Research

Background:

  • Peri-implantitis is a growing concern, linked to bone loss and implant failure.
  • It may also contribute to systemic inflammation, affecting distant organs and chronic diseases.
  • This inflammation is marked by elevated mediators like interleukin-6 (IL-6) and C-reactive protein (CRP).

Purpose of the Study:

  • To review evidence linking peri-implantitis to systemic health.
  • To explore the impact of peri-implant inflammation on chronic diseases and organ function.
  • To identify research gaps and clinical priorities.

Main Methods:

  • Synthesis of mechanistic and clinical evidence.
  • Review of studies on peri-implantitis and systemic inflammatory markers.
  • Analysis of associations between implant rehabilitation and cognitive health.

Main Results:

  • Peri-implantitis can induce a sustained systemic low-grade inflammatory state.
  • This inflammatory burden is associated with cardiovascular, renal, and neuroinflammatory complications.
  • Treating peri-implant disease may improve systemic inflammatory markers and cognitive resilience.

Conclusions:

  • Peri-implantitis extends beyond an oral condition, acting as a systemic health modifier.
  • Further research is needed to fully understand its systemic implications.
  • Clinical practice should consider the systemic impact of peri-implantitis management.