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Related Experiment Video

Updated: Mar 24, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
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Portable Bioprinter in Ischemic Wound Therapy: a Pilot Study.

D P Revokatova1, Y I Khristidis2, A L Fayzullin3

  • 1Junior Researcher, Clinical Smart Nanotechnology Laboratory, Institute for Regenerative Medicine of the Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow, 119991, Russia.

Sovremennye Tekhnologii V Meditsine
|March 23, 2026
PubMed
Summary

This study developed a novel bioprinting method for non-healing wounds using fibrin-gelatin hydrogel and adipose mesenchymal stromal cells (MSCs). The approach significantly accelerated wound healing and restored skin layers.

Keywords:
bioinkin situ bioprintingischemic woundsnon-healing woundsspheroids

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Wound Healing

Background:

  • Non-healing wounds pose a significant clinical challenge.
  • Current treatments have limitations in promoting complete tissue regeneration.

Purpose of the Study:

  • To develop and evaluate a novel bioprinting approach for treating ischemic wounds.
  • To utilize a portable bioprinter with a bioink composed of fibrin-gelatin hydrogel and adipose mesenchymal stromal cells (MSCs).

Main Methods:

  • A model of ischemic pig wound was created using mechanical compression.
  • A bioink combining fibrin-gelatin hydrogel and adipose-derived MSC spheroids was prepared using a novel passive mixer.
  • The bioink was applied to wounds using a portable Biogan bioprinter.

Main Results:

  • The bioink significantly accelerated wound healing compared to control and hydrogel-only groups.
  • Complete restoration of all skin layers was observed by day 36.
  • The therapeutic effect was attributed to MSC spheroids, not the hydrogel.

Conclusions:

  • The developed bioprinting approach using adipose-derived MSC spheroids is effective in accelerating non-healing wound closure.
  • The novel bioink formulation and portable bioprinter show promise for clinical translation.
  • MSC spheroids are the key therapeutic component for enhanced skin regeneration.