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Published on: March 3, 2023
A Case of Microwave Ablation Activating Immune Response in Pulmonary Metastases from Hepatocellular Carcinoma
Juncheng Wan1,2,3,4, Chaoqiao Jin1,2,3, Changyu Li1,2,3
1Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Abstract:
Immune checkpoint inhibitors have significantly transformed the treatment of advanced solid tumors, revolutionizing the therapeutic landscape. However, drug resistance is a key clinical obstacle to the application of immune checkpoint inhibitors in patients. We describe a patient who developed pulmonary metastases from hepatocellular carcinoma 5 years after hepatectomy. After continuous targeted therapy and immunotherapy, the lesion still progressed slowly, but after ablation of one lesion, the other lesions were significantly reduced when immunotherapy was used again. This case might provide insight into to the current low response rate to immunotherapy, providing a new direction for further exploration.
Insights
Immune checkpoint inhibitors are vital for advanced solid tumors but face drug resistance. Ablating one tumor lesion in a hepatocellular carcinoma patient enhanced immunotherapy effectiveness against other metastatic sites.
Area of Science:
- Oncology
- Immunotherapy
- Hepatocellular Carcinoma Research
Background:
- Immune checkpoint inhibitors (ICIs) have revolutionized advanced solid tumor treatment.
- Drug resistance remains a significant clinical challenge for ICI therapy.
- Hepatocellular carcinoma (HCC) is a challenging solid tumor with potential for metastasis.
