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Related Experiment Video

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Dual-Biosensor for Five Drugs Detection in Precision Oncology.

Francesca Rodino1, Myriam Briki1,2, Thierry Buclin2

  • 1Bio/CMOS Interfaces Laboratory (BCI), École Polytechnique Fédérale de Lausanne, 2000 Neuchâtel, Switzerland.

Bionanoscience
|March 23, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a novel dual-biosensor for real-time therapeutic drug monitoring (TDM) of multiple chemotherapy drugs. This point-of-care platform enhances precision oncology by enabling personalized cancer treatment.

Keywords:
BiosensorsCYPsElectrochemical sensingMWCNTsPrecision oncologyTDM

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Oncology

Background:

  • Precision medicine in oncology requires monitoring patient-specific drug responses.
  • Therapeutic drug monitoring (TDM) is vital for optimizing chemotherapy efficacy and minimizing toxicity.
  • Electrochemical biosensors offer portable, rapid, and cost-effective solutions for point-of-care applications.

Purpose of the Study:

  • To develop a novel dual-biosensor platform for simultaneous TDM of multiple chemotherapeutic agents.
  • To enable real-time, cost-effective drug monitoring for personalized cancer treatment.
  • To address patient-specific variability in drug response for improved oncology outcomes.

Main Methods:

  • Integration of multi-walled carbon nanotubes (MWCNTs) with cytochrome P450 enzymes (CYP3A4 and CYP2B6).
  • Development of a dual-electrode electrochemical sensing platform for simultaneous detection.
  • Detection of cyclophosphamide, ifosfamide, etoposide, methotrexate, and 5-fluorouracil within clinically relevant ranges.

Main Results:

  • The dual-biosensor platform demonstrated sensitive and selective detection of five key chemotherapeutic drugs.
  • Enhanced electron transfer and substrate specificity were achieved through MWCNT-enzyme integration.
  • The system successfully monitored drugs individually and in combination under simulated clinical conditions.

Conclusions:

  • The proposed dual-biosensor platform provides a portable, rapid, and cost-effective solution for TDM in precision oncology.
  • This technology facilitates real-time drug level assessment at the point-of-care, advancing personalized cancer therapy.
  • The platform enhances the precision and accessibility of cancer treatment by enabling tailored dosage adjustments.