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Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
An unusual presentation of miliary tuberculosis with medullary nephrocalcinosis in an infant
Kyle R Knutsen1, Eyassu Hailemichael2, Rita Sico3
1School of Medicine, West Virginia University, Morgantown, WV 26508, USA.
Abstract:
Miliary tuberculosis (MTB) is a rare and potentially fatal manifestation of Mycobacterium tuberculosis infection, resulting from hematogenous dissemination of the primary infection. Although more commonly seen in immunocompromised individuals, infants are also susceptible due to their immature immune systems. We present the case of an 88-day-old female with MTB and extrapulmonary disease involving the liver, spleen, kidneys, and retina. Imaging demonstrated diffuse pulmonary nodules, hepatic and splenic granulomas, and nephrocalcinosis. This case highlights the hallmark radiologic features seen in MTB and extrapulmonary disease, along with imaging of medullary nephrocalcinosis, a rare extrapulmonary manifestation.
Insights
Miliary tuberculosis (MTB) is a rare, fatal infection from Mycobacterium tuberculosis. This case details MTB in an infant with widespread organ involvement, emphasizing key radiologic findings.
Area of Science:
- Pediatric Infectious Diseases
- Radiology and Medical Imaging
- Mycobacterial Infections
Background:
- Miliary tuberculosis (MTB) is a severe, disseminated form of Mycobacterium tuberculosis infection.
- Infants are at higher risk due to immature immune systems, despite higher prevalence in immunocompromised adults.
- Extrapulmonary involvement is common in MTB, affecting multiple organs.
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