Related Experiment Video
Updated: Mar 24, 2026
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Polysensitization Patterns and Age-Dependent Allergen Profiles in Children from Suzhou, China: A Component-Resolved
Qiuyan Xu1,2, Haowei Zhao2, Yongchao Dong1
1Department of Pediatrics, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, People's Republic of China.
Insights
Pediatric allergic diseases are common, with most children showing sensitization to allergens. Allergen sensitivity patterns change with age, and many children are sensitized to multiple allergens, indicating a need for personalized treatments.
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Diagnostics
- Epidemiology of Allergic Diseases
Background:
- Allergic diseases represent a significant global health concern, particularly with increasing prevalence in children.
- Understanding allergen sensitization is crucial for effective management and prevention strategies in pediatric populations.
Purpose of the Study:
- To investigate allergen sensitization profiles, cross-reactivity, and polysensitization patterns in pediatric patients with allergic diseases in Suzhou, China.
- To provide data for the development of precise prevention and treatment strategies tailored to individual children.
- To analyze the relationship between age, gender, and specific allergen sensitization.
Main Methods:
- A cross-sectional study involving 510 children (aged 1-15 years) with suspected allergic conditions.
- Serum-specific IgE (sIgE) testing for 12 aeroallergens and 14 food allergens.
- Component-resolved diagnosis (CRD) for house dust mite (HDM)/Dust mite allergens in 120 patients.
Main Results:
- High sIgE positivity rate (74.12%) observed in the study cohort.
- Aeroallergen sensitization (90.48%) was more prevalent than food allergen sensitization (48.15%), with HDM being the most common.
- Age significantly influenced sensitization patterns, with younger children showing higher sensitization to Egg and Cow's milk, while aeroallergen sensitization increased with age.
- Polysensitization (≥3 allergens) was common (65.34%), and significant cross-reactivity was noted between certain aeroallergens and food allergens.
Conclusions:
- Pediatric allergic patients in Suzhou exhibit high rates of sIgE positivity and polysensitization.
- Age-dependent variations in allergen sensitization underscore the importance of age-specific diagnostic approaches.
- Component-resolved diagnosis (CRD) and understanding cross-reactivity are essential for advancing precision medicine in pediatric allergy.
Purpose:
Allergic diseases are a major global public health issue with a rising pediatric prevalence. This study explored the allergen sensitization profiles, cross-reactivity, and polysensitization patterns among pediatric patients with allergic diseases in Suzhou, China, to inform precision prevention and treatment.
Methods:
This cross-sectional study included 510 children aged 1-15 years suspected of having allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), and allergic asthma (AS). Serum-specific IgE (sIgE) was measured for 12 aeroallergens and 14 food allergens. Component-resolved diagnosis (CRD) was performed for house dust mite (HDM)/Dust mite allergens in 120 patients.
Results:
Of the 510 children, 378 (74.12%) tested sIgE-positive. The mean age of the sIgE-positive patients was 7.03 ± 2.79 years, with a male-to-female ratio of 1.35:1. Among the sIgE-positive patients, 56.08% had AD, 87.83% had AR, and 29.37% had AS. Aeroallergen sensitization (90.48%) was significantly higher than food allergen sensitization (48.15%), with HDM being the most common aeroallergen (71.96%). CRD showed high positivity rates for Der p 1 and Der f 1 (both 95.83%) in 120 HDM/Dust mite-sensitized patients. Age significantly affected sensitization patterns: younger children had higher Egg and Cow's milk sensitization rates, while aeroallergen (including HDM, Dust mite, and Cat dander) sensitization increased significantly with age. Most allergens showed no gender-related differences. Polysensitization was common, with 65.34% (247/378) of patients being sensitized to three or more allergens. Significant cross-reactivity was observed between certain aeroallergens and food allergens, such as a strong correlation between Der p 10 and Shellfish (ρ = 0.88) and moderate correlations between Ragweed and Sesame/Peanut (ρ = 0.53, 0.48, respectively).
Conclusion:
In Suzhou, allergic children show high sIgE positivity and polysensitization rates. Allergen sensitization varies with age, highlighting the need for age-specific diagnostics and CRD for precision medicine. Extensive cross-reactivity exists between aeroallergens and food allergens.
Related Concept Videos
02:06Allergic Reactions
01:30Drug Toxicity: Allergic Reactions
01:30Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
01:27Allergic Drug Reactions
01:30Allergic Reactions: Anaphylaxis
01:20Sputum Studies II: Culture and Sensitivity
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...