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Blunted Brain Reactivity To Mutilation Pictures in Patients with Posttraumatic Stress Disorder and Exposure To
Aline F Bastos1, Leticia de Oliveira2, Mirtes G Pereira2
1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ Brazil.
Abstract:
This study investigated the impact of childhood sexual abuse (CSA) on brain responses to aversive stimuli in patients with Posttraumatic Stress Disorder (PTSD). Whole-brain and regions-of-interest analyses revealed that participants who reported higher severity of CSA had smaller brain reactivity to mutilation versus neutral pictures in the right postcentral and supramarginal gyrus, and in the left midcingulate, suggesting that CSA may blunt brain reactivity to aversive stimuli in areas involved in sensory and emo-motoric processing. This study adds evidence for long-lasting effects of CSA on brain processing and attests the need for specific diagnosis and treatment for the affected patients with PTSD.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s40653-025-00788-w.
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