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Helicobacter pylori Infection and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis and Mendelian
Yunpeng Xu1, Junfen Li1, Cuifang He1
1The First Clinical Medical College of Lanzhou University, Lanzhou, People's Republic of China.
Helicobacter pylori infection is more common in COPD patients and linked to worse lung function. However, genetic analysis found no causal link, so routine screening isn't advised for COPD patients.
Area of Science:
- Pulmonology
- Gastroenterology
- Epidemiology
Background:
- * Helicobacter pylori (H. pylori) infection and chronic obstructive pulmonary disease (COPD) represent significant global health challenges.
- * Emerging evidence suggests a potential link between H. pylori infection and the development or progression of COPD.
Purpose of the Study:
- * To systematically evaluate the association between H. pylori infection and COPD risk using a meta-analysis.
- * To investigate the bidirectional causal relationship between H. pylori infection and COPD using Mendelian randomization.
Main Methods:
- * Meta-analysis of 27 studies (7159 participants) from Chinese and English databases.
- * Two-sample Mendelian randomization analysis utilizing genetic instruments for H. pylori antibody phenotypes and COPD GWAS summary statistics.
Main Results:
- * COPD patients exhibited a significantly higher prevalence of H. pylori infection (RR = 1.43).
- * H. pylori positivity in COPD patients was associated with poorer lung function (reduced FEV1/FVC, FEV1%, FEV1, FVC%, FVC).
- * Mendelian randomization analysis did not support a bidirectional causal relationship between H. pylori antibodies and COPD.
Conclusions:
- * H. pylori infection is more prevalent in COPD patients and correlates with reduced lung function and increased disease severity.
- * No genetic evidence supports a causal role for H. pylori in COPD.
- * Routine H. pylori screening or eradication is not currently recommended for the general COPD population.
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