Related Experiment Video
Updated: Mar 24, 2026

A Tuberculosis Molecular Bacterial Load Assay TB-MBLA
Published on: April 30, 2020
A Measurement Model to Quantify Systemic Bacilli Load in Severe HIV-Associated Tuberculosis
Bianca Sossen1, Charlotte Schutz1,2, Linda Boloko1,2
1Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, South Africa.
Abstract:
Pathogen load is considered fundamental to infection pathobiology but is unobserved or inadequately measured. We used latent variable modeling to characterize HIV-associated tuberculosis mycobacterial load in 519 inpatients. Tests on urine and blood, not sputum, showed substantial covariance. Summarizing covariance via measurement models estimated pathogen loads with stronger correlation with host inflammation and mortality than traditional measures such as blood culture time to positivity.
More Related Videos
06:26Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
Published on: July 28, 2023
08:10A Functional Whole Blood Assay to Measure Viability of Mycobacteria, using Reporter-Gene Tagged BCG or M.Tb BCG lux/M.Tb lux
Published on: September 14, 2011
Related Concept Videos
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...