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Updated: Mar 24, 2026

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Published on: May 26, 2023
Early Clinical Experience With CrossFAST, a Novel, Microcatheter-Led Delivery System for Complex Percutaneous
Michael Yang1, Frank Saltiel2, Tim A Fischell2
1Department of Cardiology, Scripps Mercy Hospital, San Diego, California.
Background:
Guide extension catheters are integral to coronary intervention. First-generation guide catheter extension devices are monorail, blunt-ended tubular structures with limitations. CrossFAST (Vantis Vascular) is a next-generation, microcatheter-led advanced device delivery system intended to allow safe, deep coronary intubation to assist in complex percutaneous coronary intervention.
Methods:
The CrossFAST device delivery system was FDA 510(k) cleared in December 2024. We describe this new technology and review 4 of the early clinical cases utilizing CrossFAST to assist in complex percutaneous coronary intervention.
Results:
The CrossFAST system was used successfully to assist in-stent delivery in all 4 of these cases: Distal right coronary artery, proximal plus mid left circumflex, mid left anterior descending, and proximal diagonal. The device crossed the target lesion in all cases, allowing seamless stent delivery without complications after conventional attempts, including guide extension catheters, had failed.
Conclusions:
The CrossFAST was used successfully in the treatment of these 4 complex, calcific, coronary artery disease cases, to assist in coronary device delivery and placement. Additional data will be needed to further evaluate the safety and efficacy of this technology as compared to conventional approaches to complex coronary artery disease.
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