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Quantizing DNA Metallization For Site-Defined Growth Of Single Quantum Emitters.

Swati Tanwar¹, Zihui Wang², Lintong Wu¹

¹Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.

Small Structures

|March 23, 2026

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This summary is machine-generated.

Researchers developed quantitative rules for reliably growing single silver nanoclusters on DNA origami. This breakthrough enables precise control over quantum emitters for advanced photonics and sensing applications.

Area of Science:

Nanotechnology
Quantum Photonics
Biomolecular Engineering

Background:

DNA-templated silver nanoclusters offer potential for subwavelength light control.
Deterministic growth of single nanoclusters on DNA has lacked clear quantitative guidelines.

Purpose of the Study:

To establish explicit quantitative criteria for reliable, site-specific nucleation of single silver nanoclusters on DNA origami.
To enable the programming of tailored emitter permutations for quantum photonics and sensing.

Main Methods:

Systematic variation of oligocytosine (OligoC) handle number and silver ion (Ag+) reduction conditions.
Utilizing DNA origami scaffolds for site-specific nanocluster synthesis.
Correlative atomic force microscopy (AFM) and single-molecule two-photon fluorescence lifetime imaging (FLIM) for characterization.

Keywords:

Ag nanocluster DNA origami DNA-assisted metallization Fluorescence lifetime imaging Nanoscale patterning

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Main Results:

Identified a 'rule-of-10' for OligoC handles and a specific AgNO3 loading window for one-nanocluster-per-site growth with nanometer precision.
Demonstrated consistent nucleation thresholds for one-, two-, and three-site arrays in both substrate-bound and solution-phase syntheses.
Verified single-emitter behavior, bright two-photon fluorescence, single-step photobleaching, and ~1.2 ns lifetimes using AFM and FLIM.

Conclusions:

Established explicit quantitative rules for predictable DNA-directed nucleation of silver nanoclusters.
Opened practical routes for creating addressable quantum emitters and scalable nanocluster arrays for integrated nanophotonics and single-molecule sensing.