Related Experiment Video
Updated: Mar 24, 2026
Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating
Published on: February 20, 2016
Preparation of Fe2O3/GCN/ICG/DHA Nanocomplexes and Their Multifunctional Combined Antitumor Properties
Junyu Liu1, Li Zhang2, Xiaoyu Zhou1
1Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, People's Republic of China.
Introduction:
Malignant tumors seriously affect people's normal lives, but the effective treatment of cancer needs to be further improved.
Methods:
In this study, we prepared nanocomposites with photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) properties named Fe2O3/GCN/ICG/DHA. Under high H2O2 conditions, Fe3+ is reduced to Fe2+ and reacts with DHA to produce C-center free radicals, which kill tumor cells. In addition, ICG produced a warming effect and cytotoxic singlet oxygen with 808 nm laser irradiation.
Results:
The significant combined antitumor activity of Fe2O3/GCN/ICG/DHA, validated in vitro and in vivo, provides strong experimental support for advancing this transition metal iron-based nanocomplex towards tumor therapy applications.
Discussion:
It expands the potential applications of novel nanocomplex in the field of tumor therapy.
