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Updated: Mar 24, 2026
Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
Published on: April 1, 2019
The exposure-lag-response association between solar radiation components and meibomian gland dysfunction in Shanghai,
Han Zhao1,2, Zile Yu3, Wushuang Wang4,5,6
1Department of Ophthalmology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Objective:
Meibomian gland dysfunction (MGD) is a prevalent cause of evaporative dry eye disease with significant public health implications. This study investigated the potential impact of solar radiation (SR) on the incidence of MGD in Shanghai, China.
Methods:
Daily information was collected in Shanghai, China, from January 1, 2017, to December 31, 2023, including air pollution, outpatient visits for MGD, meteorological data, and SR data. A distributed lag nonlinear model was used to explore the relationships between SR and MGD, taking into account potential nonlinear exposure-response relationships and lag effects. Additionally, the study used weighted quantile sum and quantile-based g-computation models to examine whether SR components independently affected MGD.
Results:
The present study identified 64,038 records of outpatient visits for MGD. Exposure to global horizontal irradiance, diffuse horizontal irradiance, and direct normal irradiance was associated with an increased risk of MGD outpatient visits at the lags of 0-3 days, 7-14 days, and 0-15 days, respectively. Furthermore, the study identified subgroup-specific effects of SR, which differed by age, gender, and season.
Conclusion:
These results underscore the importance of considering environmental factors in understanding the prevalence of MGD. The study was conducted in Shanghai, China, and provides valuable insights into the potential risk factors for MGD in this region.
