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Updated: Mar 24, 2026
Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
Published on: September 13, 2017
Knowledge, attitudes, and practices regarding osteoporosis among hormone receptor-positive breast cancer patients: a
Xiaoyan Chen1, Rongfang Xu2, Xiangyang Sun3
1Department of Breast Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, China.
Objective:
To investigate the knowledge, attitudes, and practices (KAP) concerning osteoporosis among hormone receptor-positive (HR+) breast cancer patients.
Methods:
A cross-sectional study was conducted from November, 2023, to March, 2024 among HR+ breast cancer patients to assess their KAP regarding osteoporosis. Structural equation modeling (SEM) was employed to assess the relationships among the KAP dimensions.
Results:
A total of 758 HR+ breast cancer patients were invited, 610 completed the questionnaire (response/completion rate: 80.5%), and 491 questionnaires were retained for the final analysis after prespecified data cleaning (analytic inclusion rate: 64.8%). HR+ breast cancer patients had insufficient knowledge (mean 9.69, SD 5.93), moderate attitudes (mean 29.50, SD 4.55), and moderate practices (mean 35.85, SD 4.75). SEM showed that knowledge directly influenced attitudes (β = 0.509, P < 0.001), while both knowledge (β = 0.585, P < 0.001) and attitudes (β = 0.402, P < 0.001) had direct effects on practices.
Conclusions:
HR+ breast cancer patients exhibit insufficient knowledge, positive attitudes, and suboptimal practices regarding osteoporosis.
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