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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

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Related Experiment Video

Updated: Jul 11, 2026

Standardized Measurement of Nasal Membrane Transepithelial Potential Difference NPD

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Published on: September 13, 2018

Revisiting Nasal Polyp Scoring in Clinical Trials: Interpretive Variability and the Need for Standardization

Leigh J Sowerby¹, Babak Pourmomenarabi¹, Antonino Maniaci²

¹Department of Otolaryngology-Head & Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

International Forum of Allergy & Rhinology

|March 23, 2026

Summary

No abstract available in PubMed .

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