Related Experiment Video
Updated: Mar 24, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Advances in the Different Synthetic Routes of Fluorinated Hydrazines
Dimitra Kyrko1, Benoît Crousse1
1Université Paris-Saclay, CNRS, BioCIS, Orsay, France.
Abstract:
Hydrazine derivatives are widely used in various research fields, including pharmaceuticals, agrochemicals, polymers, and industrial dyes, as well as serving as precursors in organic synthesis. Given the importance of this scaffold and the growing interest in fluorine's ability to confer specific properties on molecules, the synthesis of fluorinated hydrazines has attracted considerable attention from researchers. This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N-fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
More Related Videos
14:11Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Preparation of Nitriles
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview