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Decreased Length of Locus Coeruleus Norepinephrine Axons and Increased Amyloid Beta Pathology in Male APP/PS1 Mice

Ivy J Z Garland1, Shaydel Engel1, Matthew Scalf1

  • 1Department of Pharmacology, University of Minnesota, Medical School, Minneapolis, MN, 55455, USA.

Neurotoxicity Research
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PubMed
Abstract

No abstract available in PubMed .

Keywords:
AlcoholAmyloid betaLocus coeruleusMaleMotor cortex

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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