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Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
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Recent progress in T-cell malignancies including adult T-cell leukemia-lymphoma
1Cancer Center, Kumamoto University Hospital, Kumamoto, Japan. knosaka@kumamoto-u.ac.jp.
International Journal of Hematology
|March 23, 2026
Summary
Recent advancements refine T-cell lymphoma classifications using molecular and viral insights. Novel targeted therapies and stem cell transplantation offer improved treatment strategies for these diverse lymphoid malignancies.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- T-cell lymphomas are diverse lymphoid malignancies with poor prognoses.
- Recent classifications (WHO 5th ed., ICC 2022) integrate molecular and cytokine profiles.
- Understanding molecular drivers is crucial for therapeutic development.
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