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Comprehensive Safety Evaluation of Ekangveer Rasa: A Herbo-Metallic Ayurvedic Formulation in Wistar Rats Following

Shatrughna Madhukar Bajad1,2, Monika Kumari1, Shripad Rajendra Kshirsagar1,2

  • 1Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, Telangana, India.

Biological Trace Element Research
|March 23, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Biochemical parametersBiodistributionEkangveer rasaGene expressionGenotoxicityLead

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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