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Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Related Experiment Video

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Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
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Risk Factors for Union Deformities in Fifth Metatarsal Fractures: A Scoping Review.

Date Van der Meij1,2, Bradley Weaver1, Alireza Ebrahimi1

  • 1Foot and Ankle Research and Innovation Lab (FARIL), Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Foot & Ankle Specialist
|March 23, 2026
PubMed
Summary
This summary is machine-generated.

Union deformities in fifth metatarsal (5MT) fractures are common. Key factors influencing healing include fracture zone, fixation method, and early activity, with bone grafting improving outcomes.

Keywords:
Jones fracturedelayed unionmetatarsal fracturenonunionpredictionstress fracture

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Area of Science:

  • Orthopedic Surgery
  • Podiatric Medicine
  • Sports Medicine

Background:

  • Proximal fifth metatarsal (5MT) fractures frequently result in union deformities after treatment.
  • Identifying risk factors is crucial for predicting and managing these fractures.

Purpose of the Study:

  • To systematically review and summarize the risk factors associated with delayed or nonunion in 5MT fractures.

Main Methods:

  • A comprehensive literature search was conducted across major medical databases.
  • Methodological quality was assessed using the MINORS tool.
  • Data on healing rates, complications, fracture characteristics, and treatment outcomes were extracted from 13 eligible studies.

Main Results:

  • Fracture zone (especially zone 2), plantar gap >1 mm, small screw diameter, and premature return to activity predict nonunion.
  • Surgical treatment accelerated union but increased risks of delayed union and refracture.
  • Bone grafting and larger screw diameters enhanced union rates.

Conclusions:

  • Fracture zone, chronicity, and fixation strategy significantly impact 5MT fracture healing and union deformities.
  • Risk stratification and tailored treatments can minimize nonunion and improve patient recovery.
  • Further high-quality research is needed for standardized definitions and protocols.