Funginocarterphenyls A-C: thiazole-containing p-terphenyls from Paulkirkia sp. KT4190

Funginocarterphenyls A-C (1-3), which are thiazole-containing p-terphenyls, were identified from the fungus Paulkirkia sp. KT4190. Although structurally related p-terphenyls, such as nocarterphenyls (Wang et al. 2019) and echoside D (Deng et al. 2014), have been reported from actinomycete strains, these compounds represent the first examples isolated from filamentous fungi. The substitution pattern of the central hexasubstituted benzene ring was established via detailed hetero multiple-bond correlation spectral analyses. This was further verified by density-functional-theory-based chemical-shift calculations. Time-course analysis of compound production suggested their biosynthetic sequence.