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Molecular insights into Candida auris glycosylphosphatidylinositol transamidase

Xuyang Ding1,2, Zhengkang Hua1,2, Di Zhang2

  • 1Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases and Hubei Key Laboratory of Natural Active Polysaccharides, Huazhong University of Science and Technology, Wuhan, 430030, China.

Protein & Cell
|March 23, 2026
PubMed
Abstract

No abstract available in PubMed .

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Antifungal Agents01:15

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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