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Updated: Mar 25, 2026

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

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Published on: March 14, 2020

Primary sclerosing cholangitis.

Erik von Seth¹, Tom H Karlsen², Atsushi Tanaka³

¹Department of Upper Gastrointestinal Disease, Karolinska University Hospital, Stockholm, Sweden; Unit of Gastroenterology and Nutrition, Karolinska Institutet, Stockholm, Sweden.

Lancet (London, England)

|March 23, 2026

Summary

This summary is machine-generated.

Primary sclerosing cholangitis (PSC) is a rare liver disease often linked with inflammatory bowel disease. Its cause is unclear, but the gut microbiome plays a key role in PSC development and progression.

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Area of Science:

Hepatology
Gastroenterology
Immunology

Background:

Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease marked by biliary inflammation and fibrosis.
It frequently co-occurs with inflammatory bowel disease (IBD), increasing risks for hepatobiliary and colorectal cancers.
PSC progression involves bile duct fibrosis, liver cirrhosis, and potential need for transplantation, with disease recurrence post-transplant.

Purpose of the Study:

To explore the clinical features of primary sclerosing cholangitis.
To summarize current understanding of PSC pathogenesis, including genetic and environmental factors.
To provide insights into managing PSC, highlighting challenges and opportunities.

Main Methods:

Literature review and synthesis of current research on PSC.
Analysis of clinical presentations and disease progression patterns.
Discussion of the role of the intestinal microbiome in PSC.

Main Results:

PSC presentation is variable, often diagnosed asymptomatically, but can advance to symptoms like itching, fatigue, and pain.
The exact cause and pathogenesis of PSC remain unclear, with genetic and environmental factors implicated.
The intestinal microbiome is increasingly recognized for its crucial role in PSC development, progression, and outcomes.

Conclusions:

Effective treatments for PSC are limited, underscoring the need for further research.
Understanding the interplay between genetics, environment, and the microbiome is key to unraveling PSC pathogenesis.
Future management strategies may leverage microbiome-targeted therapies for PSC.