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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

Updated: Mar 25, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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A framework for rapid, repeatable, and high-fidelity whole-brain multi-pool CEST imaging at 3 T.

Yupeng Wu1, Siyuan Fang1, Siyuan Wang2

  • 1Shanghai Key Laboratory of Magnetic Resonance, Institute of Magnetic Resonance and Molecular Imaging in Medicine, School of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.

Magnetic Resonance Imaging
|March 23, 2026
PubMed
Summary
This summary is machine-generated.

A new framework enables fast, accurate whole-brain multi-pool chemical exchange saturation transfer (CEST) imaging. This validated method improves repeatability and reduces artifacts for reliable brain metabolic imaging.

Keywords:
Amide proton transfer (APT)Chemical exchange saturation transfer (CEST)Multi-poolTrue fast imaging with steady-state precession (True FISP)Whole-brain

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High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Neuroimaging

Background:

  • Chemical Exchange Saturation Transfer (CEST) imaging offers metabolic insights but faces challenges like long scan times and confounding factors.
  • Developing rapid and accurate CEST techniques is crucial for clinical translation and broader application in neuroscience.

Purpose of the Study:

  • To create and validate a framework for fast, accurate, and repeatable whole-brain, multi-pool CEST imaging at 3 Tesla.
  • To address limitations of long acquisition times and confounding factors in quantitative CEST.

Main Methods:

  • Optimized a single-shot 3D True FISP sequence for whole-brain multi-pool CEST acquisition.
  • Implemented rapid B0, B1, and T1 mapping with a dual-echo modified four-angle method.
  • Developed a neural network for B1 correction and utilized the AREX metric for T1 and MT correction.

Main Results:

  • Achieved high-quality, whole-brain CEST images in ~9 minutes with minimal artifacts.
  • Demonstrated significant reduction in coefficient of variation (CV) for MTR_LD and APT_AREX after B1 and AREX correction.
  • Showcased excellent agreement between neural network B1 correction and conventional methods (ICC > 0.95) and high test-retest repeatability (average CV < 10% for 95/96 regions).

Conclusions:

  • Successfully developed and validated a rapid, robust framework for quantitative whole-brain multi-pool CEST imaging.
  • The integrated approach overcomes key barriers to clinical translation for CEST imaging.
  • Enables reliable metabolic imaging for diverse brain pathologies.