Biosynthetically natural product-conserved scaffolds: Harnessing power with molecular-medicinal strategy for new...

This perspective demonstrates a critical analysis of natural products-conserved scaffolds, the molecular architectures that are produced in the common T-point of naturally evolved various biosynthetic pathways. It presents structure and functional correlation of T-point molecules with preclinical agents and drug molecules and molecule-to-medicinal properties (pharmacodynamic, physicochemical, ADMET and pharmacokinetic). Cheminformatic analysis reinforces the scaffolds' structural and functional relevance. This analysis is valuable to serve as a guiding model for development of "Nature-to-new" therapeutic molecular space.