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Discovery of anti-adipogenic acetylenic acids from Malaina oleifera seed meal
Shi-Heng Zong1, Xiao-Cui Liu2, Min He2
1State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Key Laboratory of State Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650224, PR China.
Abstract:
Eight previously undescribed acetylenic acids (1-8) and one known acetylenic acid (9) were firstly isolated from Malania oleifera seed meal. The absolute configurations were determined by extensive spectral analysis, the bulkiness rule, and NMR calculations. All compounds were evaluated for their inhibitory effects on lipid accumulation in oleic acid (OA)-induced 3T3-L1 cells. The results showed that compounds 1 and 2 exhibited moderate anti-adipogenesis effects than the positive control (LiCl, 10 mM), with IC50 values of 40.45 μM and 25.20 μM, respectively.
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