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Dual Photothermal and Magnetothermal Responsive Shape Memory Polyurethane with Magnetic Navigation Capability
Zhiyou Xue1, Maosheng Zhang1, Sizhe Tao1
1State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
ACS Applied Materials & Interfaces
|March 23, 2026
Summary
This study introduces a magnetic shape memory polymer (MPU) for biomedical uses. The MPU offers precise navigation and dual thermal activation, showing potential for advanced medical devices.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Shape memory polymers (SMPs) are crucial for biomedical applications but face challenges with remote activation, including limited tissue penetration and control.
- Existing activation methods for SMPs often lack the precision and depth required for complex in vivo procedures.
Purpose of the Study:
- To develop a multifunctional shape memory polymer system with enhanced remote activation and magnetic navigation capabilities.
- To integrate magnetic nanoparticles for dual-mode thermal triggering and precise spatial control in biomedical applications.
Main Methods:
- Synthesized a magnetic polyurethane (MPU) incorporating Fe3O4 nanoparticles and neodymium-iron-boron (NdFeB) microparticles.
- Utilized external magnetic fields for NdFeB microparticle magnetization and navigation.
- Employed near-infrared II (NIR-II) light and alternating magnetic fields (AMF) for dual photothermal and magnetothermal activation.
Main Results:
- The MPU demonstrated superior magnetic navigation control and rapid, efficient shape recovery with high ratios.
- Fe3O4 nanoparticles enabled dual-mode thermal activation (NIR-II and AMF), offering precise spatial-temporal control.
- The MPU exhibited excellent mechanical properties, biocompatibility, and minimal cytotoxicity in cell studies.
Conclusions:
- The developed MPU system successfully integrates magnetic navigation and dual-mode thermal activation for advanced biomedical applications.
- The material shows significant promise for minimally invasive surgical instruments, smart tissue scaffolds, and targeted drug delivery systems.
- This platform addresses limitations of traditional SMP activation, paving the way for more sophisticated medical interventions.
