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Related Experiment Video

Updated: Mar 25, 2026

Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

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Published on: July 16, 2014

Effective Brain Targeting Using the Self-Emulsifying Drug Delivery Systems.

Shruti Gawde¹, Yogeshwar Bachhav², Maushmi S Kumar³

¹Somaiya Institute for Research and Consultancy (SIRAC), Somaiya Vidyavihar University, Vidyavihar (East), Mumbai, 400077, India.

AAPS Pharmscitech

|March 24, 2026

Summary

Self-emulsifying drug delivery systems (SEDDS) enhance neurotherapeutic transport across the blood-brain barrier (BBB). This review explores SEDDS formulation, AI optimization, and clinical translation for brain drug delivery.

Keywords:

Central nervous system (CNS) targeting Self-emulsifying drug delivery systems (SEDDS), blood–brain barrier (BBB) permeability intranasal nano formulations neurotherapeutics oral nano formulations

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Last Updated: Mar 25, 2026

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Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

Area of Science:

Nanotechnology and Pharmaceutical Sciences
Neuroscience and Drug Delivery

Background:

The blood-brain barrier (BBB) significantly restricts the delivery of neurotherapeutics to the central nervous system.
Self-emulsifying drug delivery systems (SEDDS) represent a promising nanocarrier approach to overcome BBB limitations for lipophilic drugs.

Purpose of the Study:

To review the formulation, mechanisms, and translational potential of SEDDS for enhancing neurotherapeutic delivery across the BBB.
To explore advancements in SEDDS, including ligand-functionalized and AI-optimized systems, for improved brain drug targeting.

Main Methods:

Comprehensive literature review of SEDDS formulation principles, excipient selection, and BBB transport mechanisms.
Evaluation of oral and intranasal SEDDS, innovative SEDDS modifications (ligand-functionalized, hybrid, mucoadhesive).
Discussion of AI/ML tools for formulation design, PBPK modeling, and comparative analysis with experimental data.

Main Results:

SEDDS demonstrate potential for improving solubility, permeability, and targeted delivery of lipophilic neurotherapeutics.
AI/ML and PBPK modeling offer advanced tools for optimizing SEDDS preformulation and predicting pharmacokinetic behavior.
Preclinical data, patent landscape, and innovation trajectories suggest growing clinical readiness for SEDDS.

Conclusions:

SEDDS are a viable strategy for overcoming BBB challenges in neurotherapeutics, with ongoing innovations enhancing their potential.
Addressing challenges in excipient safety, scale-up, and regulatory compliance is crucial for successful clinical translation.
Future research should focus on optimizing SEDDS formulations and leveraging advanced modeling for efficient neurotherapeutic delivery.