Related Experiment Video

Updated: Mar 25, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.4K

Sociodemographic and Clinical Factors Impact Non-Live Vaccine Coverage After Pediatric Solid Organ Transplantation: A

Adam Z Blatt1, Yunfei Wang2, Yeh-Chung Chang3

  • 1Levine Children's Hospital, USA.

Pediatric Transplantation
|March 24, 2026
PubMed

Insights

Pediatric solid organ transplant recipients often have delayed or incomplete childhood vaccinations. Factors like younger age at transplant, heart transplants, and private insurance were linked to lower vaccination rates, highlighting gaps in care.

Area of Science:

  • Immunology
  • Pediatric Medicine
  • Transplantation

Background:

  • Pediatric solid organ transplant (SOT) recipients face higher risks of vaccine-preventable diseases (VPDs).
  • Immunosuppression and under-vaccination contribute to this increased vulnerability.
  • Guidelines recommend post-transplant immunization and serologic monitoring, but adherence can be inconsistent.

Purpose of the Study:

  • To evaluate adherence to post-transplant vaccination guidelines in pediatric SOT recipients.
  • To identify factors associated with delayed or incomplete vaccination schedules.
  • To improve vaccine coverage and protection against VPDs in this population.

Main Methods:

  • Retrospective study of 199 pediatric SOT recipients (heart, intestinal/multi-visceral, kidney, liver).
  • Assessed adherence to serologic monitoring post-vaccination.
  • Identified sociodemographic and clinical factors linked to vaccination timeliness and completion.

Main Results:

  • Serologic monitoring was used in only 8% of recommended vaccinations.
  • Younger age at transplant, heart transplant, and private insurance were negatively associated with timely vaccination.
  • These factors correlated with delayed or incomplete non-live vaccine schedules.

Conclusions:

  • Significant gaps exist in post-transplant vaccination monitoring and adherence.
  • Age at transplant, heart transplantation, and insurance type are key factors influencing under-immunization.
  • Further investigation is needed to address these modifiable gaps and optimize VPD protection.
Abstract

Keywords:
pediatricsolid organtransplantvaccines

More Related Videos

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.8K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

15.0K

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
681
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.2K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
458
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
554
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
327
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
410