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Related Experiment Video

Updated: Mar 25, 2026

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Testing for Network Specificity in Brain-Behavior Associations Using Ordinal Dominance Curves.

Noah Hillman1, Sarah M Weinstein2, Joëlle Bagautdinova3,4,5

  • 1Penn Statistics in Imaging and Visualization Endeavor, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Human Brain Mapping
|March 24, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces NETDOM, a new statistical method for brain mapping. NETDOM accurately identifies brain-behavior associations, improving upon existing network enrichment testing methods.

Keywords:
brain networksbrain‐behavior associationsbrain‐wide association studiesenrichmenthypothesis testingintersection–union testingordinal dominance curves

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Area of Science:

  • Neuroscience
  • Brain Mapping
  • Statistical Methods

Background:

  • Interpreting brain-behavior relationships commonly uses anatomical or functional brain networks.
  • Statistical methods for testing enrichment of these associations within specific brain regions are underdeveloped.

Purpose of the Study:

  • To propose and validate a novel permutation-based approach for network enrichment testing, named NETDOM.
  • To address limitations in current statistical methods for identifying localized brain-behavior associations.

Main Methods:

  • Developed NETDOM, a permutation-based approach utilizing ordinal dominance curves.
  • Conducted simulation studies to assess NETDOM's type I error rate and statistical power.
  • Applied NETDOM to large-scale neurodevelopmental cohort data.

Main Results:

  • NETDOM effectively controls the type I error rate, outperforming other methods.
  • NETDOM demonstrates increased statistical power, especially when enrichment is localized within networks.
  • Successfully detected enriched associations between brain measures and neurocognitive performance in real-world data.

Conclusions:

  • NETDOM is a statistically sound and powerful tool for network enrichment testing in brain mapping.
  • The method advances the analysis of brain-behavior relationships in neurodevelopmental studies.
  • NETDOM offers improved detection of localized brain-behavior associations.