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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Published on: October 15, 2019

Relationship Between Gut Microbiota and Cancer Neuro-Immunity.

Danyang Wang¹, Ruirui Cui², Chang You³

¹The Second School of Clinical Medicine, Nanjing Medical University, Nanjing, China.

Microbial Biotechnology

|March 24, 2026

Summary

This summary is machine-generated.

The gut microbiota influences cancer progression and treatment response through neuroimmune pathways. Understanding these interactions can lead to novel microbiota-based therapies to improve cancer immunotherapy efficacy.

Keywords:

gut microbiota immunotherapy neuroimmunity tumour microenvironment

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Area of Science:

Oncology
Immunology
Microbiology
Neuroscience

Background:

The nervous system and immune system are key in the tumor microenvironment, influencing metastasis, immune evasion, and metabolism.
The interplay between gut microbiota and cancer neuro-immunity is not well understood, limiting insights into tumor progression and treatment resistance.

Purpose of the Study:

To systematically explore the interactions among gut microbiota, nervous system, and immune system in regulating tumor progression.
To elucidate how gut microbiota metabolites modulate tumor phenotypes via neuroimmune mechanisms.
To summarize how cancer neuro-immunity shapes gut microbiota composition and its role in immunotherapy.

Main Methods:

Systematic review of existing literature on gut microbiota, neuro-immunity, and cancer.
Analysis of pathways linking gut microbiota metabolites to tumor phenotypes through neuroimmune signaling.
Exploration of the bidirectional relationship between cancer neuro-immunity and gut microbiota composition.

Main Results:

Gut microbiota and its metabolites significantly influence tumor progression and therapeutic resistance via neuroimmune pathways.
Cancer neuro-immunity reciprocally shapes the gut microbiota composition.
There is a complex interplay between immunotherapy and cancer neuro-immunity.

Conclusions:

Targeting the gut microbiota offers potential for novel cancer therapies.
Microbiota-based interventions like fecal microbiota transplantation, probiotics, prebiotics, and synbiotics may enhance immunotherapy efficacy through neuroimmune mechanisms.