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Refractory Heart Failure in Noncompaction Cardiomyopathy Despite Guideline-Directed Therapy: A Case Series

Varshitha Tumkur Panduranga1, Asher Gorantla1, Nana Osei1

  • 1Internal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.

Cureus
|March 24, 2026
PubMed

Insights

Noncompaction cardiomyopathy (NCCM) with heart failure with reduced ejection fraction (HFrEF) shows limited response to guideline-directed medical therapy (GDMT). Advanced interventions may be necessary for improved outcomes in these rare cases.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Noncompaction cardiomyopathy (NCCM) is a rare congenital heart muscle disease.
  • It is characterized by excessive left ventricular trabeculations and deep intertrabecular recesses.
  • NCCM is associated with significant morbidity and mortality, including heart failure, arrhythmias, and thromboembolism.

Keywords:
guideline-directed medical therapyheart failure with reduced ejection fractionimplantable cardioverter-defibrillatornon-compaction cardiomyopathyrefractory heart failure

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