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Updated: Mar 25, 2026
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Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
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Intranasal Nano-Delivery Systems: Emerging Strategies for Central Nervous System Disease Therapeutics
Tong Gao1, Qihui Chu2, Xiaomin Xing1
1Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China.
International Journal of Nanomedicine
|March 24, 2026
Summary
Nasal drug delivery offers a non-invasive route to the brain, bypassing the blood-brain barrier (BBB). Advanced nanocarriers enhance this nose-to-brain delivery for treating central nervous system (CNS) diseases.
Area of Science:
- Neuroscience
- Pharmaceutics
- Biotechnology
Background:
- Central nervous system (CNS) diseases are increasing globally.
- The blood-brain barrier (BBB) severely restricts effective drug delivery to the brain.
- Nasal administration presents a promising non-invasive strategy to bypass the BBB via direct neural pathways.
Purpose of the Study:
- To review nasal transport pathways for brain delivery.
- To discuss the design of advanced nano-delivery systems for CNS therapeutics.
- To analyze challenges and future trends in nose-to-brain drug delivery.
Main Methods:
- Literature review integrating mechanistic insights of nasal transport.
- Analysis of nano-carrier properties for enhanced mucosal penetration and brain accumulation.
- Consolidation of recent advances in nasal nano-delivery systems for CNS disorders.
Main Results:
- Nasal delivery utilizes olfactory and trigeminal pathways, systemic absorption, or lymphatic drainage.
- Optimized nano-carriers improve drug penetration, retention, and accumulation in the brain.
- Nasal nano-delivery systems enhance brain targeting, efficacy, and reduce systemic toxicity for CNS disorders.
Conclusions:
- Nasal nano-delivery systems show significant potential for treating CNS diseases.
- Overcoming nasal barriers and optimizing nanocarrier design are crucial for efficacy.
- Addressing clinical translation challenges like safety and scalability is essential for future development.
Keywords:
blood-brain barriercentral nervous system diseasesintranasal deliverynano-delivery systemsnasal-brainMore Related Videos
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