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Updated: Mar 25, 2026

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Serum Sickness After Cosmetic Botulinum Toxin Type A Injections
None:
Botulinum toxin type A (BoNT-A) is widely used in therapeutic and cosmetic settings for neuromuscular and aesthetic indications. Although generally well tolerated, reports of hypersensitivity reactions-ranging from localized erythema to systemic immune syndromes-underscore its immunological complexity. This case report and literature review demonstrates a novel case of serum sickness following cosmetic Botox® (onabotulinumtoxin-A, Allergan Aesthetics, an AbbVie company, Irvine, CA) administration, categorizes hypersensitivity reactions according to the Gell and Coombs classification (Types I-IV), explores the role of complexing proteins and formulation excipients, and highlights emerging clinical concerns. This will underscore the need for greater vigilance in identifying systemic immune responses to BoNT-A especially within the cosmetic medicine industry. Level of Evidence: 5 (Therapeutic).
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