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Related Experiment Video

Updated: Mar 25, 2026

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence
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A Chemical Probe for Prostate-Specific Membrane Antigen for Real-Time Raman Imaging of Prostate Cancer Cells.

William J Tipping1, Daniel J Powell2, Robert C Wells1

  • 1Centre for Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow G1 1RD, U.K.

ACS Sensors
|March 24, 2026
PubMed
Summary

A new small molecule probe, PSMA-BADY, enables precise intraoperative detection of prostate cancer using stimulated Raman scattering (SRS) microscopy. This advance aids in accurately identifying tumor margins for improved patient treatment outcomes.

Keywords:
biosensorsimagingprostate cancerprostate-specific membrane antigenstimulated Raman scattering microscopy

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Area of Science:

  • Biomedical Optics
  • Molecular Imaging
  • Surgical Oncology

Background:

  • Accurate intraoperative detection of localized prostate cancer is critical for effective long-term treatment.
  • Current optical imaging methods often rely on theranostic agents for tumor margin delineation.

Purpose of the Study:

  • To develop a novel small molecule probe for targeted prostate cancer detection using stimulated Raman scattering (SRS) microscopy.
  • To create a probe that specifically targets prostate-specific membrane antigen (PSMA) for enhanced visualization.

Main Methods:

  • Development of the PSMA-BADY probe by incorporating an alkyne tag into a high-affinity glutamate-ureido-lysine moiety.
  • Evaluation of probe selectivity and specificity in prostate cancer cell models with varying PSMA expression levels.
  • Utilizing stimulated Raman scattering (SRS) microscopy for high-resolution imaging.

Main Results:

  • The PSMA-BADY probe demonstrated high affinity and specificity for prostate-specific membrane antigen (PSMA).
  • Successful localization of PSMA in multicellular prostate cancer models was achieved using SRS microscopy.
  • The probe's selectivity was confirmed in cell lines with known PSMA expression profiles.

Conclusions:

  • PSMA-BADY is the first small molecule probe designed for PSMA-targeted detection via SRS microscopy.
  • This probe shows significant potential for intraoperative localization of prostate cancer.
  • The developed imaging approach offers improved accuracy in determining tumor margins during surgery.