Related Experiment Video
Updated: Mar 25, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
Nanogels for the targeted delivery of antibiotic and antimicrobial drugs
Humberto D Escobedo1, Michael J Schurr2, Devatha P Nair1,3
1Department of Carniofacial, Oral and Materials Sciences, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Abstract:
Nanoparticle-based drug delivery systems represent a promising platform for advancing biomedical therapies. Among them, nanogels - three‑dimensional, crosslinked polymer networks - offer tunable structures that enable targeted and controlled drug delivery, a key advantage in combating antimicrobial resistance. Recognized by the World Health Organization as a major global health threat, antimicrobial resistance continues to rise due to the overuse, misuse, and improper dosing of antibiotics in human and veterinary medicine. Resistant bacterial strains often form biofilms that further reduce antibiotic effectiveness, underscoring the need for delivery platforms that enhance targeting while minimizing off‑target exposure. Nanogels are well-positioned to address these challenges. Recent in vivo studies, sourced from Google Scholar and PubMed between 2020 and 2026, demonstrate their ability to improve antimicrobial therapy through efficient drug loading, controlled release, and site‑specific delivery. This review highlights these advances and discusses remaining obstacles, including scaling up nanogel production and the potential role of artificial intelligence in optimizing nanogel design and manufacturing to support standardized, cost‑effective, and clinically viable treatments.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Site-Targeted
Inhibitors of Bacterial Protein Synthesis
Inhibitors of Gram-positive Cell Wall Synthesis

