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Benign Peripheral Nerve Sheath Tumors: Recurrence Rates and Pain Outcomes Following Excision.

Floris V Raasveld1,2,3, Tareq Hanna2, Fernando J Pacheco2

  • 1. Division of Plastic and Reconstructive Surgery, Department of General Surgery, Massachusetts General Hospital, Harvard University, Boston, MA.

Plastic and Reconstructive Surgery
|March 24, 2026
PubMed
Summary
This summary is machine-generated.

Benign peripheral nerve sheath tumors (bPNSTs) most often occur in extremities. Neurofibromas, NF1, and specific patient factors increase recurrence risk after surgery.

Keywords:
Benign peripheral nerve sheath tumordistributionneurofibromapainrecurrenceschwannoma

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Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Benign peripheral nerve sheath tumors (bPNSTs) pose surgical challenges due to their proximity to critical neural structures.
  • Understanding the distribution and recurrence patterns of bPNSTs is crucial for optimizing surgical outcomes.

Purpose of the Study:

  • To investigate the anatomical distribution of bPNSTs.
  • To analyze recurrence rates and identify factors associated with bPNST recurrence post-excision.

Main Methods:

  • Retrospective analysis of 228 patients who underwent bPNST resection.
  • Assessment of tumor location, histology, recurrence rates, and pain outcomes.
  • Bivariate analyses to identify predictors of recurrence.

Main Results:

  • bPNSTs predominantly affect the extremities (upper 45.2%, lower 44.3%).
  • Schwannomas (76.3%) were more common than neurofibromas (22.4%).
  • Overall recurrence rate was 7.0%, with higher rates for neurofibromas (15.7%) and patients with NF1 (19.4%). Postoperative motor deficits, psychiatric comorbidities, and younger age were linked to increased recurrence.

Conclusions:

  • bPNSTs are most common in extremities, with schwannomas being the predominant subtype.
  • Neurofibromas, NF1, postoperative motor deficits, psychiatric comorbidities, and younger age are associated with higher recurrence risk.
  • This data aids surgical planning and patient counseling for bPNSTs.